Egg Donor Medication
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Learn More About Medications
Understanding the Hormone Medication Process
Hormone medications play a vital role in the egg donation procedure, helping to stimulate the development of multiple mature eggs. It’s important to understand that each individual egg donor may respond differently to these medications. Some donors experience no side effects whatsoever, while others may notice mild and temporary changes.
The fertility clinic will provide you with comprehensive instructions on how to self-administer the medications. These are typically given through small, subcutaneous injections into the fatty tissue of the abdomen, similar to giving yourself an insulin shot. The clinic staff will provide thorough training and ensure you feel comfortable with the injection process.
While the risks associated with these medications are low and the side effects are generally temporary, some donors may experience symptoms such as headaches, moodiness, bloating, and hot flashes. It’s important to remember that every woman’s body is unique. You may experience all, some, or none of these potential side effects. Our team and the clinic staff will closely monitor you throughout this phase and are available to address any concerns you may have.
List of The Medications
GNRH AGONIST – Leuprolide Acetate
Lupron:
One injection per day for approximately 12 days, then one injection per day in conjunction with gonadotropin therapy for a total of 22 days.
The administration of GNH agonist medicine like Lupron is used to prevent release of eggs and to control some of the female hormone levels. Specifically, it affects the pituitary gland and results in lower luteinizing hormone (LH) and follicle stimulating hormone (FSH) in the body. This approach is used to achieve a response to the IVF medicines and reduce the likelihood of an egg donation cycle being canceled.
These medications are harmless and leave your system immediately after discontinue use.
GNRH Antagonist
Ganirelix acetate or Cetrotide:
One injection per day or every 3 days taken with gonadotropin therapy. Typically it is added after being on the gonadotropin therapy for 5 days. It is taken for approximately 6 days.
This is used instead of the GNRH agonist medicine Lupron to prevent the eggs from ovulating during the stimulation and allows for more control of the cycle.
Follicle Stimulating Hormones (FSH or Gonadotropins)
Gonal F, Bravelle, Follistim, Memopur, Repronex:
One injection per day for approximately 10 days.
FSH is the very same hormone produced by a woman’s body to mature the eggs within the ovaries during her reproductive cycle. Each egg in the ovary sits in a sac called a follicle. In the treatment of egg donation, FSH medicine is given to develop many follicles and thus make many eggs. The more ovarian follicles produced, the greater chances are for a successful outcome.
Side Effects:
OHSS (ovarian hyperstimulation syndrome) The incidence of severe OHSS is 1-2% of IVF cases. OHSS means that the body has over-responded to the FSH and the ovaries become enlarged. The physician is very careful to avoid this from happening. Should an egg donor experience pain, it is important to seek treatment to avoid serious complications.
Human Chorionic Gonadotropin (HCG or “Trigger Shot”)
Ovidrel, Profasi, Pregnyl:
One injection approximately 24 hours prior to egg retrieval.
HCG is the name of the pregnancy hormone and is produced by the human placenta. The purpose of administering HCG is to mature the eggs before they are retrieved, like when the sun ripens a fruit. Once the follicles are the right size the egg inside needs to ripen or become mature; HCG medicine makes this happen. It is very important to take this injection because without it the eggs would not be usable for IVF.
During retrieval you will be given a light IV sedation for the egg retrieval procedure to ensure their comfort. Under ultrasound guidance, the fertility doctor will pass a needle through the vaginal wall and aspirate the follicle fluid which contains the eggs. Egg retrieval is a short procedure, generally lasting 30 minutes or less.
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