Gestational Surrogacy Medications

Surrogate Medications

Learn more about surrogate medications. The medications involved in a gestational surrogacy cycle are listed below. Please note that each surrogate responds differently to her individual medication. Some surrogates will experience no side effects at all. You will also have the opportunity to discuss the fertility clinic’s specific protocol with your IVF nurse at your medical evaluation appointment.


Use: Doxycycline is a pre-cycle antibiotic that prevents any possible low-grade pelvic infection.

Side Effects: None, but varies per individual.

Administration: Oral tablet.

LUPRON (leuprolide acetate)

Use: Lupron prevents the usual hormone exchange that causes follicle production and ovulation by suppressing the pituitary stimulation to the ovaries.

Side Effects: Headache, fatigue, hot flashes.

Administration: Lupron is an injection given subcutaneously (in the fatty tissue) by a ½ inch needle under the skin.


Use: Aspirin assists with cycle stimulation and impending embryonic implantation. This medication will continue until 12 weeks of pregnancy.

Side Effects: Upset stomach, heartburn, easy bruising or bleeding.

Administration: Oral tablet.


Use: Estrogen is a hormone that helps grow the lining of the uterus which maintains an early pregnancy.

Side Effects: Skin redness, irritation or rash, nausea, fluid retention.

Administration: The patch is applied to the skin on the abdomen and the estrogen is absorbed through the skin.